4E-BP1 (N63) pAb

Cat no: BS1376

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.

Catalogue number:	BS1376
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q13541
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 32-81of Human 4E-BP1.
Species:	4E-BP1 (N63) pAb detects endogenous levels of 4E-BP1 protein.
Molecular weight:	~ 15 to 20 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	EIF4EBP1; 4E-BP1; 4EBP1; PHAS-I
Additional info:	For research use only, not for use in diagnostic procedure.

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4E-BP1 (N63) pAb

Cat no: BS1376

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