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ACCalpha (H74) Peptide

Cat no: BS1378P

ACCalpha (H74) Peptide

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl- CoA carboxylase in human muscle. ACCalpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCbeta (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCalpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACCalpha, which maps to human chromosome 17, encodes the 265 kDa alpha form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCbeta is homologous to that of ACCalpha except for an additional peptide of about 150 amino acids at the N-terminus.

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SPECIFICATIONS

Catalog Number

BS1378P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide ACCalpha (H74). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q13085

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1378 ACCalpha (H74) pAb.

Alternative Names

Acetyl-CoA carboxylase 1; Short name=ACC1; ACC-alpha; Biotin carboxylase; ACACA; ACAC; ACC1; ACCA

SUPPLIER INFO

Bioworld Technology, Inc.

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