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ACOT8 (P172) pAb

ACOT8 (P172) pAb

Cat no: BS3062

Supplier: Bioworld Technology, Inc.
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ACOT8 (Acyl-CoA thioesterase 8) also designated, TEII p35 or hTE, is a novel human thioesterase that has been found to interact with the HIV protein Nef using yeast two-hybrid screening. Nef is an auxiliary gene of the human immunodeficiency virus (HIV) which facilitates virus replication and enhances infectivity. The roles of Nef in HIV-infected cells are likely to be mediated by specific interactions with cellular proteins. The interaction between Nef and ACOT8 is correlated with CD4 downregulation, suggesting that ACOT8 may be involved in Nef-mediated CD4 downregulation in HIV-infected cells. ACOT8 is 42% identical to thioesterase II from Escherichia coli, and it has no significant homology with the two types of animal thioesterases that have previously been cloned (type I and type II thioesterases).
Catalogue number: BS3062
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: O14734
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 151-200 of Human ACOT8.
Species: ACOT8 (P172) pAb detects endogenous levels of ACOT8 protein.
Molecular weight: ~ 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Acyl-coenzyme A thioesterase 8; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II; hACTE-III; hACTEIII; hTE; ACOT8; ACTEIII; PTE1; PTE2
Additional info: For research use only, not for use in diagnostic procedure.

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