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Actinin-(alpha)1/2/3/4 (W48) pAb

Actinin-(alpha)1/2/3/4 (W48) pAb

Cat no: BS2206

Supplier: Bioworld Technology, Inc.
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The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and (alpha)-actinins. There are four tissue-specific (alpha)-actinins, namely (alpha)-actinin-1, (alpha)-actinin-2, (alpha)-actinin-3 and (alpha)-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each (alpha)-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding (alpha)-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
Catalogue number: BS2206
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P12814/P35609/Q08043/O43707
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 30-60 of Human Actinin-(alpha)1.
Species: Actinin-(alpha)1/2/3/4 (W48) pAb detects endogenous levels of total (alpha)-actinin protein.
Molecular weight: ~ 103 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: pan-(alpha)-Actinin; (alpha)-Actinin-pan; Actinin-(alpha); Actinin (alpha); (alpha) Actinin; (alpha)-Actinin; Alpha-actinin-4; F-actin cross-linking protein; Non-muscle alpha-actinin 4; ACTN4; (alpha)-Actinin4; Actinin (alpha)4; Actinin(alpha)4; (alpha)Actinin-4; Actinin-(alpha)4; (alpha)-actinin-4; Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; Non-muscle alpha-actinin-1; ACTN1; (alpha)-Actinin1; Actinin (alpha)1; Actinin(alpha)1; (alpha)Actinin-1; Actinin-(alpha)1; (alpha)-actinin-1; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; ACTN2; (alpha)-Actinin2; Actinin (alpha)2; Actinin(alpha)2; (alpha)Actinin-2; Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; ACTN3; (alpha)-Actinin3; Actinin (alpha)3; Actinin(alpha)3; (alpha)Actinin-3; Actinin-(alpha)3; (alpha)-actinin-2; (alpha)-actinin-3
Additional info: For research use only, not for use in diagnostic procedure.

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