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Actinin-(alpha)2/3 (Q58) pAb

Actinin-(alpha)2/3 (Q58) pAb

Cat no: BS1984


Supplier: Bioworld Technology, Inc.
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The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and (alpha)-actinins. There are four tissue-specific (alpha)-actinins, namely (alpha)-actinin-1, (alpha)-actinin-2, (alpha)-actinin-3 and (alpha)-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each (alpha)-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding (alpha)-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

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