Actinin-alpha3 (E25) Peptide

The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and alpha-actinins. There are four tissue-specific alpha-actinins, namely alpha-actinin-1, alpha-actinin-2, alpha-actinin-3 and alpha-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each alpha-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding alpha-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

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SPECIFICATIONS

Catalog Number

BS2205P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Actinin-alpha3 (E25). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q08043

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2205 Actinin-alpha3 (E25) pAb.

Alternative Names

Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; ACTN3; alpha-Actinin3; Actinin alpha3; Actininalpha3; alphaActinin-3; Actinin-alpha3; alpha-actinin-3