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Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)

Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)

Cat no: A0850

Supplier: United States Biological
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Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6�,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentao�xo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-ox�o-3H-phenoxazine-1,9-dicarboxamide Purity: (same/more than)95% Appearance: Orange to red-brown crystaline powder Identity: Conforms to USP reference Potency: (same/more than)900u/mg Specific Rotation:-292 to -317 Heavy Metals: <0.001% Loss on Drying: (same/less than) 5% RNase:None Detected DNase: None Detected Protease: None Detected Residue on Ignition: (same/less than)0.1% Endotoxin: (same/less than)100EU/mg Working concentration: 0.01 to 2ug/ml Solublility: Dimethyl sulfoxide (DMSO) 1mg/ml Light and moisture sensitive.
Catalogue number: A0850
Size: 25mg
Alternative names: Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1
References: US Biological application reference: Nelson, S.A. et al., (2000) Gene 253:87-93. 1. Merck Index, 11:441, #2804 (1989). 2. Meienhofer, J., J. Amer. Chem Soc., 92:3771 (1970). 3. United States Pharmacopoeia, XXII:379 (1990). 4. Singh, A.P.,et al., Can. J. Microbiol.,18 (6), 909 (1972).

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