Adducin (alpha) (K439) pAb

Adducins are a family of cytoskeleton proteins encoded by three genes ((alpha), (beta), (gamma)). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin (alpha) is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin (alpha) and Adducin (gamma) is ubiquitous in contrast to the restricted expression of Adducin (beta). Adducin (beta) is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.

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SPECIFICATIONS

Catalog Number

BS1435

Size

100ug/100ul

Applications

IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 400-450 of Human Adducin (alpha).

Species

Adducin (alpha) (K439) pAb detects endogenous levels of Adducin (alpha) protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200\nIF: 1:50~1:200

Swiss Prot

P35611

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul