Home  >  Products  >  Adenosine A2a Receptor (A2aR)
Adenosine A2a Receptor (A2aR)

Adenosine A2a Receptor (A2aR)

Cat no: A0869-56A1

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A2aAR is a glycoprotein that can activate adenylyl cyclase via Gs interactions. Stimulation of A2aAR and the resultant accumulation of cAMP inhibits platelet aggregation and in certain vascular beds is associated with vasodilation and drop in blood pressure. A2aAR is reported to interact with D2 dopamine receptor sites in the brain where they co-express (striatum, olfactory tubercle and nucleus accumbens). Other tissues including heart, kidney, and lung also express A2aAR. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 detects an ~45kD protein from canine striatum representing A2aAR. Immunohistochemistry (paraffin-embedded sections): 1:100. Staining of A2aAR in human hippocampus yeilds a pattern consistent with plasma memrane staining. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0869-56A1
Reactivities: Human, Canine
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Alternative names: ADORA2A, HGNC:263, RDC8, hA2aR, Adenosine Receptor Subtype A2a
References: Olah ME & Stiles GL Adenosine receptor subtypes: characterization and therapeutic regulation. Annu Rev Pharmacol Toxicol 35:581-606 (1995). Palmer TM & Stiles GL Adenosine receptors. Neuropharmacology 34:683-94 (1995).
Additional info: Recognizes canine adenosine receptor A2a at ~45kD. Does not detect other AR subtypes. Species Crossreactivity: human

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave