Adiponectin (mouse) BioAssay(TM) ELISA Kit (ACRP30, AdipoQ, apM1, GBP28, Adipocyte complement related protein of 30kD)

Adiponectin is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium).\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C

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SPECIFICATIONS

Catalog Number

044470

Size

96Tests

References

Product Reference: \n?Chop-deficient mice showed increased adiposity but no glucose intolerance: Y. Ariyama, et al.; Obesity 15, 1647 (2007)\n?Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by highcalorie diet: S. Otabe, et al.; Am. J. Physiol. Endocrinol. Metab. 293, E210 (2007)\n?Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes: J. Ahn, et al.; BBRC 364, 972 (2007)\n?Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis: H. Nakayama, et al.; Metabolism 56, 470 (2007)\n?Anti-diabetic Effects of Compound K versus Metformin versus Compound K-Metformin Combination Therapy in Diabetic db/db Mice: S.H. Yoon, et al.; Biol. Pharm. Bull. 30, 2196 (2007)\n?Compound K Enhances Insulin Secretion with Beneficial Metabolic Effects in db/db Mice: G.C. Han, et al.; J. Agric. Food Chem. 55, 10641 (2007)\n?Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes: M. Kobayashi, et al.; Endocrinology 149, 5662 (2008)\n?A Vinegar-processed Ginseng Radix (Ginsam) Ameliorates Hyperglycemia and Dyslipidemia in C57BL/KsJ db/db Mice: E.J. Han, et al.; Food Sci. Biotechnol. 17, 1228 (2008)\n?Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice: H. Nakayama, et al.; Metabolism 58, 901 (2009)\n?Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus: M.H. Nan, et al.; J. Drug Target. 18, 67 (2010)\n?ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport: L. Xu, et al.; Horm. Metab. Res. 42, 643 (2010)\n?Feeding silk protein hydrolysates to C57BL/KsJ-db/db mice improves blood glucose and lipid profiles: E.Y. Jung, et al.; Nutr. Res. 30, 783 (2010)\n?Hyperadiponectinemia enhances bone formation in mice: Y. Mitsui, et al.; BMC Musculoskelet. Disord. 12, 18 (2011)\n?A promising culture model for analyzing the interaction between adipose tissue and cardiomyocytes: M. Anan, et al.; Endocrinology 152, 1599 (2011)\n?

Additional Info

Detects mouse adiponectin. Does not cross-react with human adiponectin, rat adiponectin, mouse resistin, mouse RELM-beta or mouse leptin.

Alternative Names

ACRP30, AdipoQ, apM1, GBP28, Adipocyte complement related protein of 30kDa