AGER / RAGE (E182) Peptide

Cat no: BS3448P

Supplier: Bioworld Technology, Inc.

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Additional Information

Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

Catalogue number:	BS3448P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q15109
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide AGER / RAGE (E182). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Receptor for advanced glycosylation end products; Advanced glycosylation end product-specific receptor; AGER; RAGE
Additional info:	This peptide can be used with studies using BS3448 AGER / RAGE (E182) pAb.

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AGER / RAGE (E182) Peptide

Cat no: BS3448P

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