Ah Receptor (Aryl Hydrocarbon Receptor, AHR)

Aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450.\n\nPositive Control: Respiratory Epithelium and Bronchial Smooth Muscle\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1059-72V

Size

50ug

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Pab

Purity

Purified by peptide immunoaffinity chromatography.

References

1. Korkalainen M, Tuomisto J, and Pohjanvirta R. The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor. Biochem Biophys Res Commun (285):1121-9 (2001 Aug). 2. Korkalainen M, Tuomisto J, and PohjanvirtaR.Restructured transactivation domain in hamster AH receptor. Biochem Biophys Res Commun (273):272-81 (2000 Jun). 3. Hahn ME. The aryl hydrocarbon receptor: a comparative perspective.Comp Biochem Physiol C Pharmacol Toxicol Endocrinol (121):23-53 (1998 Nov). 4. Pohjanvirta R, Wong JM, Li W, Harper PA, Tuomisto J, and Okey AB. Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol Pharmacol (54):86-93 (1998 Jul). 5. Hahn ME, Karchner SI, Shapiro MA, and Perera SA. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci USA (94):13743-8 (1997 Dec).

Additional Info

This antibody is specific to the human AHR protein. Species Crossreactivity: Human. Other species not tested.

Alternative Names

Dioxin Receptor