AIM2 (A78) pAb

Cat no: BS2393

Supplier: Bioworld Technology, Inc.

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Interferon-inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-(gamma), AIM2 is thought to act as a tumor suppressor by repressing NFkB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of (alpha)-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase-1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers.

Catalogue number:	BS2393
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	O14862
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 51-100 of Human AIM2.
Species:	AIM2 (A78) pAb detects endogenous levels of AIM2 protein.
Molecular weight:	~ 39 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Absent in melanoma 2; AIM 2; Aim2; AIM2; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4;
Additional info:	For research use only, not for use in diagnostic procedure.

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AIM2 (A78) pAb

Cat no: BS2393

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