AIM2 (A78) Peptide

Cat no: BS2393P

Supplier: Bioworld Technology, Inc.

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Interferon-inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-gamma , AIM2 is thought to act as a tumor suppressor by repressing NFkB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of alpha-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase-1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers.

Catalogue number:	BS2393P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O14862
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide AIM2 (A78). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Absent in melanoma 2; AIM 2; Aim2; AIM2; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4;
Additional info:	This peptide can be used with studies using BS2393 AIM2 (A78) pAb.

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AIM2 (A78) Peptide

Cat no: BS2393P

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