Aldehyde Dehydrogenase 1A1 (Aldh1a1, Acetaldehyde Dehydrogenase 1, AHD2, ALDC, Aldehyde Dehydrogenase 1 Soluble, Aldehyde Dehydrogenase 1A1, Aldehyde Dehydrogenase Cytosolic, Aldehyde Dehydrogenase Liver (cytosolic), MGC2318, PUMB1, RALDH 1, RalDH1, Retin

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1334-33A

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Everts HB, King LE Jr, Sundberg JP, Ong DE. . Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation.. J Invest Dermatol. 2004 Aug;123(2):258-63. . PMID: 15245423

Additional Info

Species Crossreactivity: Human. Other Species have not been tested. Expected crossreactivity based upon sequence homology: Human, Mouse, Rat