Home  >  Products  >  Aldehyde Dehydrogenase 1A1 (Aldh1a1, Acetaldehyde Dehydrogenase 1, AHD2, ALDC, Aldehyde Dehydrogenase 1 Soluble, Aldehyde Dehydrogenase 1A1, MGC2318, PUMB1, RALDH 1, RalDH1, Retinal Dehydrogenase 1)
Aldehyde Dehydrogenase 1A1 (Aldh1a1, Acetaldehyde Dehydrogenase 1, AHD2, ALDC, Aldehyde Dehydrogenase 1 Soluble, Aldehyde Dehydrogenase 1A1, MGC2318, PUMB1, RALDH 1, RalDH1, Retinal Dehydrogenase 1)

Aldehyde Dehydrogenase 1A1 (Aldh1a1, Acetaldehyde Dehydrogenase 1, AHD2, ALDC, Aldehyde Dehydrogenase 1 Soluble, Aldehyde Dehydrogenase 1A1, MGC2318, PUMB1, RALDH 1, RalDH1, Retinal Dehydrogenase 1)

Cat no: A1334-33E

Supplier: United States Biological
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Acetaldehyde dehydrogenase (ALDH) is the next enzyme after alcohol dehydrogenase in the major pathways of alcohol metabolism. Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3). Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:100-250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: A1334-33E
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Serum
References: 1. Yoshida A, et al. Alcohol 2(1): 103-6, 1985. 2. Agarwal DP, et al. Enzyme 42(1): 47-52, 1989 3. Collard F, et al. Biochimie 89(3): 369-73, 2007.
Additional info: Recognizes human Aldh1a1

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