Aldehyde Dehydrogenase Family 7 Member A1 (Aldh7a1, Alpha-Aminoadipic Semialdehyde Dehydrogenase, Alpha-AASA Dehydrogenase, Delta1-Piperideine-6-Carboxylate Dehydrogenease, P6c Dehydrogenase, Antiquitin-1)

Antiquitin (Aldh7a1) is an evolutionarily conserved protein believed to play a role in the regulation of cellular turgor. Based on sequence analysis, this protein is classified as a member of the aldehyde dehydrogenase superfamily (1). Analysis of the amount of mRNA in various rat and human tissues indicates that the largest amounts are found in rat kidney and liver and in cultured human hepatoma cells. Only minimal amounts were detected in human peripheral blood leukocytes, rat lung, or cultured human fibroblasts (2). The plant homolog of ATQ1 is thought to be involved in regulating turgor pressure, a function that also would be essential for cells of the mammalian cochlea. Northern blots of 13 human fetal tissues show antiquitin to be highly expressed in cochlea, ovary, eye, heart, and kidney (3).\n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:10,000 \nImmunoprecipitation: 1:40 \nImmunohistochemistry: 1:100-1:250 \nImmunocytochemistry: 1:250-1:500 \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1334-37C

Size

100ul

Applications

ICC, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Yoshida A, et al. Alcohol 2(1): 103-6, 1985. 2. Agarwal DP, et al. Enzyme 42(1): 47-52, 1989 \n 3. Collard F, et al. Biochimie 89(3): 369-73, 2007.

Additional Info

Recognizes human Aldh7a1. Species Crossreactivity: Mouse.