Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death.
Used in the preparation of baculoviral stocks.
Appearance:
Yellow to orange, crystalline powder
Identification (FAB/MS):
Conforms to reference
Solubility:
Soluble in DMSO and DMF/HCl
Amphotericin B is poorly soluble in water.
Potentcy:
(same/more than)750ug/mg
Loss on Drying:
(same/less than)5.0%
Endotoxin:
(same/less than)2Eu/mg
Storage:
Store at 4 degrees C. Light sensitive.
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