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AMPK(alpha)1/2 (N180) pAb

AMPK(alpha)1/2 (N180) pAb

Cat no: BS5503

Supplier: Bioworld Technology, Inc.
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AMPK is a heterotrimeric complex comprising a catalytic (alpha) subunit and regulatory (beta) and (gamma) subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPK(alpha)1 and AMPK(alpha)2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPK(beta)1 encodes a 271 amino acid protein and human AMPK(beta)2 encodes a 272 amino acid protein. The human AMPK(gamma)1 gene encodes a 331 amino acid protein. Human AMPK(gamma)2 and AMPK(gamma)3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
Catalogue number: BS5503
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q13131/P54646
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 150-200 of Human AMPK(alpha)1.
Species: AMPK(alpha)1/2 (N180) pAb detects endogenous levels of AMPK(alpha)1 and AMPK(alpha)2 protein.
Molecular weight: ~ 63 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; au-protein kinase PRKAA1; PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; PRKAA2; AMPK; AMPK2
Additional info: For research use only, not for use in diagnostic procedure.

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