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Apaf-1-ALT (H324) Peptide

Cat no: BS1016P

Apaf-1-ALT (H324) Peptide

APAF-1-ALT harbors the caspase recruitment domain and an incomplete CED-4 like/ATPase domain, but lacks the WD-40 repeat units. The LNCaP cell expressed the full-length APAF-1 weakly and APAF-1-ALT rather abundantly, especially after mycoplasma infection. LNCaP underwent a retarded DNA damage-induced apoptosis, which was independent of caspase 9 activity. APAF-1-ALT functioned less effectively in inducing apoptosis than did APAF-1-XL, the full-length APAF-1, in transient transfection. Moreover, APAF-1-ALT interfered with APAF-1-XL's ability to induce apoptosis in transient double transfection experiment. These results indicate that APAF-1-ALT is a molecule that is deficient and impeded for mediating apoptosis and that it may contribute to the resistance to DNA damage-induced treatment observed in LNCaP.

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SPECIFICATIONS

Catalog Number

BS1016P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Apaf-1-ALT (H324). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O14727-6

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1016 Apaf-1-ALT (H324) pAb.

Alternative Names

Apaf-1 Isoform 6; APAF1 Isoform 6;

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