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APC (Q2829) Peptide

Cat no: BS1017P

APC (Q2829) Peptide

Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

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SPECIFICATIONS

Catalog Number

BS1017P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide APC (Q2829). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P25054

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1017 APC (Q2829) pAb.

Alternative Names

Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5; APC; DP2.5

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