AR-(alpha)2A (R361) pAb

Cat no: BS2254

Supplier: Bioworld Technology, Inc.

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This study investigates the involvement of (alpha)2-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that (alpha)2A-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal (alpha)2A-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, (alpha)1D-AR, were not changed by the treatment. Moreover, (alpha)o-subunits of GTP-binding proteins (G(alpha)o), one of the downstream molecules of (alpha)2A-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of (alpha)2A-AR in the mouse hippocampus.

Catalogue number:	BS2254
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P08913
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 331-380 of Human AR-(alpha)2A.
Species:	AR (alpha)2A (R361) pAb detects endogenous levels of AR (alpha)2A protein.
Molecular weight:	~ 48, 54 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR; ADRA2A; ADRA2R; ADRAR; (alpha)-2A adrenoceptor; (alpha)-2AAR; AR(alpha)-2A; AR (alpha)2A; AR(alpha)2A; AR(alpha) 2A;
Additional info:	For research use only, not for use in diagnostic procedure.

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AR-(alpha)2A (R361) pAb

Cat no: BS2254

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