ARF GAP1 (M204) pAb

ARFGAP1 (ADP-ribosylation factor GTPase activating protein 1), also known as ARF1 GAP, is a 406 amino acid protein that contains one ARF-GAP domain and localizes to the cytoplasm and the golgi apparatus. Functioning as a GTPase-activating protein (GAP), ARFGAP1 interacts with ARF1 and promotes hydrolysis of ARF1-bound GTP, an event that is required for both the dissociation of coat proteins from golgi structures and for the subsequent fusion of golgi vesicles with target compartments. When overexpressed, ARFGAP1, whose activity is inhibited by phosphatidylcholine and stimulated by phosphoinosides, can induce the redistribution of the entire golgi apparatus to the endoplasmic reticulum. Multiple isoforms of ARFGAP1 exist due to alternative splicing events.

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SPECIFICATIONS

Catalog Number

BS3066

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 170-220of Human ARF GAP1.

Species

ARF GAP1 (M204)pAb detects endogenous levels of ARF GAP1 protein

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

Q8N6T3

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 44 kDa

Alternative Names

ADP-ribosylation factor GTPase-activating protein 1,ARF GAP 1 ,ADP-ribosylation factor 1 GTPase-activating protein,ARF1 GAP,ARF1-directed GTPase-activating protein,ARFGAP1,ARF1GAP