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Ascochlorin (Antibiotic LL-Z 1272 gamma)

Cat no: A3690


Supplier: United States Biological
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The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Catalogue number: A3690
Size: 500ug
Purity: >95% by HPLC
Alternative names: Antibiotic LL-Z 1272 gamma
References: 1. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. Hong S. et al. J. Biol. Chem. 2005, 280, 25202. 2. Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Sakaguchi K. et al. Biochem. Biophys. Res. Commun. 2005, 329, 46. 3. Ascochlorin derivatives as ligands for nuclear hormone receptors. Togashi M. et al. J. Med. Chem. 2003, 46, 4113.

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