ASXL1, ID (ASXL1, KIAA0978, Putative Polycomb group protein ASXL1, Additional sex combs-like protein 1) (APC)

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:50-100\nFlow Cytometry: 1:10-50\nImmunofluorescence: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

032151-APC

Size

200ul

Applications

ELISA, FC, IF, IHC, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Abdel-Wahab, O., et al. Leukemia 24(9):1656-1657(2010)\nSzpurka, H., et al. Leuk. Res. 34(8):969-973(2010)\nSugimoto, Y., et al. Br. J. Haematol. 150(1):83-87(2010)\nBoultwood, J., et al. Leukemia 24(6):1139-1145(2010)\nRocquain, J., et al. BMC Cancer 10, 401 (2010) :

Additional Info

Mouse

Alternative Names

ASXL1, KIAA0978, Putative Polycomb group protein ASXL1, Additional sex combs-like protein 1