ATF4, phosphorylated (pS245) (Tax-responsive enhancer element B67, ATF4 protein) (Biotin)

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.\n\nApplications:\nSuitable for use in Dot Blot, ELISA\n\nRecommended Dilution:\nELISA1:1,000 \nDot blot 1:500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

032162-Biotin

Size

200ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by peptide immunoaffinity chromatography.

Isotype

IgG

References

Gombart,A.F., J. Leukoc. Biol. 81 (6), 1535-1547 (2007) Jousse,C., J. Biol. Chem. 282 (21), 15851-15861 (2007) Kakiuchi,C., Neurosci. Lett. 417 (3), 316-321 (2007) Marchand,A., J. Biol. Chem. 281 (28), 19124-19133 (2006)

Additional Info

Human

Alternative Names

Tax-responsive enhancer element B67, ATF4 protein