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Avermectin B1a (5-O-Demethylavermectin A1a, Antibiotic C 076B1a)

Avermectin B1a (5-O-Demethylavermectin A1a, Antibiotic C 076B1a)

Cat no: A4447

Supplier: United States Biological
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Avermectin B1a is the major component (>80%) of the commerically available anthelmintic Abamectin (R) used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 24-position. In vitro and in vivo studies have shown this analogue is the more potent analogue in the commerical product. Purity: >99% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Related to: Avermectin B1b, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin
Catalogue number: A4447
Size: 1mg
Purity: >99% by HPLC
Alternative names: 5-O-Demethylavermectin A1a, Antibiotic C 076B1a.
References: 1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062. 2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. Cully D.F. et al. Mol Pharmacol. 1991, 40, 326. 3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.

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