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Avermectin B1b (Antibiotic C 076B1b)

Cat no: A4447-01

Avermectin B1b (Antibiotic C 076B1b)

Avermectin B1b is the minor component (<20%) of the commerically available anthelmintic marketed as Abamectin(R) used to control parasitic nematodes in livestock. Avermectin B1b contains a isopropyl residue in the 24-position. In vitro and in vivo studies have shown this analogue to be active but less potent than the B1a analogue\n\nPurity: >99% by HPLC\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO.\n\nRelated to: Avermectin B1a, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin

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SPECIFICATIONS

Catalog Number

A4447-01

Size

1mg

Purity

>99% by HPLC\n

References

1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by \nreducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062. \n2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. \nCully D.F. et al. Mol Pharmacol. 1991, 40, 326. \n3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. \nWolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.

Alternative Names

Antibiotic C 076B1b

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