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Bax inhibitor 1 (BI-1, Testis-enhanced Gene Transcript Protein, Transmembrane BAX Inhibitor Motif-containing Protein 6, TMBIM6, BI1, TEGT)

Cat no: B1098-05B

Bax inhibitor 1 (BI-1, Testis-enhanced Gene Transcript Protein, Transmembrane BAX Inhibitor Motif-containing Protein 6, TMBIM6, BI1, TEGT)

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress

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SPECIFICATIONS

Catalog Number

B1098-05B

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2b,k

References

1. Bailly-Maitre B, E Bard-Chapeau, F Lucian, N Droin, JM Bruey, B Faustin, C Kress, JM Zapata and JC Reed. 2007. Mice lacking bi-1 gene show accelerated liver regeneration. Cancer Res 67:1442-1450.

Additional Info

Recognizes human BI-1. Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of BI-1 Species Crossreactivity: mouse and rat

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SUPPLIER INFO

United States Biological

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Bov, Prc

More info

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum, Bov, Prc

More info

Applications

IP

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum, Bov, Prc

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

More info

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