BCL2L13 pAb

The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.

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SPECIFICATIONS

Catalog Number

BS6021

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human BCL2L13.

Species

BCL2L13 pAb detects endogenous levels of BCL2L13 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q9BXK5

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 53 kDa

Alternative Names

Apoptosis facilitator; \nB2L13; \nBcl 2 like 13; \nBcl 2 like 13 protein; \nBcl-2-like protein 13; \nBcl-rambo; \nBCL2 like 13 apoptosis facilitator; \nBCL2 like 13; \nBcl2 like 13 protein; \nBcl2-L-13; \nBCL2L13; \nMIL 1; \nMIL1; \nMIL1 protein; \nProtein Mil1