BIVM (Basic, Immunoglobulin-like Variable Motif-containing)

BIVM (for basic, immunoglobulin-like variable motif-containing) refers to a recently identified gene product that maps to human chromosome 13q32-q33 and is predicted to encode a 503-amino acid protein. BIVM shows ubiquitous expression in normal human tissue and the presence of a 5' CpG island suggests it is a housekeeping gene. BIVM is likely essential for some aspect of basic cellular function. BIVM is highly charged and localizes to the cytoplasm and nucleus where it may bind to either DNA or RNA or associate with other cellular proteins. Significant sequence homology exists with many organisms.\n\nCellular Localization: Cytoplasmic and Nuclear\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5000-1:25,000.\nWestern Blot: 1:1000.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

B2102-51A

Size

50ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Can, Ch/Bird

Form

0.01% Sodium Azide; 0.15M Sodium chloride, 0.02M Potassium phosphate. pH 7

P Type

Pab

Purity

As reported

Isotype

IgG

References

Yoder JA et al. BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia. Genomics 79:750-5 (2002). <PUBMED:12036287>

Additional Info

Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Chicken (100% identity with immunogen), Chimpanzee (100% identity with immunogen) and canine (100% identity with immunogen) due to sequence homology.