BKBeta4 (BK Channel Subunit Beta-4)

BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.\n\nApplications: \nSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunofluorescence: 1-10ug/ml\nWestern Blot: 1ug/ml\nImmunohistochemistry: 0.1-1ug/ml\nImmunocytochemistry: 0.1-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

136759

Size

100ug

Applications

ICC, IF, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.4, 50% glycerol.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2A

References

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1-13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481-1489.

Additional Info

Recognizes mouse BK Beta4 at ~24kD. Species Crossreactivity: human, rat. Does not react with BKBeta1, BKBeta2 or BKBeta3.

Alternative Names

BK Channel Subunit Beta-4