BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes.
Source:
Recombinant corresponding to 86aa from mouse BLC expressed in E. coli.
Molecular Weight:
~9.8kD
Endotoxin: (same/less than)0.1ng/ug
Biological Activity:
The biological activity was determined by measuring dose-dependent chemotaxis with murine B lymphocytes. A concentration range of 10-100ng/ml produced significant chemotaxis. BLC, a CXC chemokine, regulates B cell migration to and within lymphoid follicles in most secondary lymphoid organs. The receptor for BLC is CXCR5.
Storage and Stability:
Store at -20 degrees C. Reconstitute to nominal volume by adding sterile ddH2O, 0.1-1% BSA. Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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