BRCAA1 (D810) pAb

The breast cancer-associated antigen BRCAA1, also designated ARID domaincontaining protein 4B (ARID4B), Sin3-associated polypeptide p180 (SAP180),or Retinoblastoma-binding protein 1-like 1 (RBBP1L1 or RBP1L1), shares 37% amino acid identity and an identical antigen epitope, SSKKQKRSHK, with Rb binding protein 1. High expression of BRCAA1 mRNA has been found in human breast, lung, colon, pancreatic and ovarian cancers, as well as in normal testis. This expression pattern indicates that BRCAA1 can be uses as a molecular marker for a broad range of human malignancies. BRCAA1 also interacts with RBBP1/ARID4A and regulates genomic imprinting at the Prader-WIlli syndrome (PWS)/Angelman syndrome (AS) domain.

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SPECIFICATIONS

Catalog Number

BS2935

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 776-832 of Human BRCAA1.

Species

BRCAA1 (D810) pAb detects endogenous levels of BRCAA1 protein.

Dilutions

WB: 1:500~1:1000\r

Swiss Prot

Q4LE39

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 150 kDa

Alternative Names

AT-rich interactive domain-containing protein 4B; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Histone deacetylase complex subunit SAP180; Retinoblastoma-binding protein 1-like 1; ARID4B; BRCAA1; RBBP1L1; RBP1L1; SAP180