CA125 Cancer Antigen (Ovarian Cancer)

MUC16/CA125 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16/CA125 is a high molecular mass glycoprotein.\n\nAccording to the ISOBM-TD-1 workshop, CA125 contains three antigenic domains: A-domain (Oc125), B-domain (M11), C-Domain (Ov197). The CA-125 antigen is present on a mucin-like glycoprotein of >200kD and is detectable on the apical surface of normal endometrium and endocervix. \n\nApplications: Immunohistochemistry (frozen & formalin/paraffin). \n\nRecommended Dilution:\nImmunohistochemistry: 1:25-1:50. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min.\nOptimal dilutions to be determined by the researcher.

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SPECIFICATIONS

Catalog Number

C0050-17

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as concentrated tissue culture supernatant in 15mM sodium azide.

P Type

Mab

Purity

Tissue culture supernatant

Isotype

IgG1

References

1.Alagoz T, Buller R E, Berman M, et al. What is a normal CA125 level? Gynecologic Oncology. 53:93-97 (1994).\n2. Macri C I, and Vasilev S A. Highly elevated CA125 and tubo-ovarian abscess mimicking ovarian carcinoma. Gynecologic and Obstetric Investigation. 37: 143-144 (1994).\n3. Ohmori T, Okada K, Tabei R, et al. CA125 producing adenocarcinoma of the seminal vesicle. Pathology International. 4:333-337 (1994).\n

Additional Info

Recognizes CA125 (Ovarian Cancer Antigen). Species Reactivity: Human.