CARD6 (A2) pAb

Cat no: BS1038

Supplier: Bioworld Technology, Inc.

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Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins, CARD 6, CARD 8-12 and CARD 14. CARD 6 is a 311 amino acid protein that associates with microtubules and acts as a selective mediator of NFkB activation. CARD 6 is structurally and functionally related to the superfamily of interferon (IFN)-inducible GTPases, a group that comprises host defense proteins which mediate cell-autonomous immunity. RICK, the receptorinteracting protein (RIP)-like interacting caspase-like apoptosis regulatory protein kinase, interacts with CARD 6 and targets it to aggresomes, regions of the cell where protein aggregates collect.

Catalogue number:	BS1038
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q9BX69
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to the N-terminual of Human CARD6.
Species:	CARD6/CINCIN1 (A2) pAb detects endogenous levels of CARD6/CIN protein.
Molecular weight:	~ 116 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	CARD containing inhibitor of Nod1 and Cardiak-induced NF kB activation; Caspase recruitment domain family; member 6; Caspase recruitment domain protein 6
Additional info:	For research use only, not for use in diagnostic procedure.

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CARD6 (A2) pAb

Cat no: BS1038

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