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Casein Kinase I(alpha) (F158) pAb

Casein Kinase I(alpha) (F158) pAb

Cat no: BS2001

Supplier: Bioworld Technology, Inc.
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Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKI(alpha), (beta), (gamma), e and (delta), have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an (alpha)2(beta)2 or an (alpha)(alpha)'(beta)2 structure. The a catalytic subunit is stimulated by the (beta) regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
Catalogue number: BS2001
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P48729
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 150-200 of Human Casein Kinase I(alpha).
Species: Casein Kinase I(alpha) (F158) pAb detects endogenous levels of Casein Kinase I(alpha) protein.
Molecular weight: ~ 42 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1; CKI(alpha); CK-I(alpha); CKI-(alpha); CK I(alpha);
Additional info: For research use only, not for use in diagnostic procedure.

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