CASP6, NT (CASP6, MCH2, Caspase-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11) (FITC)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

033217-FITC

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Wurstle, M.L., et al. J. Biol. Chem. 285(43):33209-33218(2010)\nLee, S.Y., et al. J Thorac Oncol 5(8):1152-1158(2010)\nHalawani, D., et al. J. Neurosci. 30(17):6132-6142(2010)\nKim, M.S., et al. APMIS 118(4):308-312(2010)\nYoo, N.J., et al. Tumori 96(1):138-142(2010)

Additional Info

Human

Alternative Names

CASP6, MCH2, Caspase-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11