Cathepsin S Cell-Based Assay Kit

Cathepsin S is a lysosomal cysteine protease involved in MHC II antigen processing and presentation. It serves a critical role in various immune system-related diseases and appears to be involved in tumor metastasis, obesity, and diabetes. Cayman's Cathepsin S Cell-Based Assay Kit employs the cathepsin S-specific substrate, Ac-KQKLR-AMC which, upon cleavage by the active enzyme, generates a highly fluorescent product that can be measured using excitation and emission wavelengths of 354 and 442 nm, respectively.

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SPECIFICATIONS

Catalog Number

600740

Form

1 ea

P Type

Assay Kits

Weight

0

Storage Temp

-80

Shipping Temp

-80

Additional Info

Cathepsin S is a lysosomal cysteine protease involved in MHC II antigen processing and presentation. It serves a critical role in various immune system-related diseases and appears to be involved in tumor metastasis, obesity, and diabetes Cayman's Cathepsin S Cell-Based Assay Kit employs the cathepsin S-specific substrate, Ac-KQKLR-AMC which, upon cleavage by the active enzyme, generates a highly fluorescent product that can be measured using excitation and emission wavelengths of 354 and 442 nm, respectively. The kit is easy to use and can be easily adapted to high throughput screening for therapeutic compounds regulating the activity of cathepsin S. A Raw 264.7 cell lysate supernatant, which contains a high level of cathepsin S activity, is included in the kit for use as a positive control. A specific cathepsin S inhibitor, Z-Phe-Leu-COCHO, is also included in the kit to demonstrate specificity of the substrate.