CCL4 pAb

Cat no: BS6854

Supplier: Bioworld Technology, Inc.

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Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1(alpha), MIP-1(beta), MIP-2, MIP-3(alpha), MIP-3(beta), MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1(beta) is more selective than MIP-1(alpha), primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1(alpha) is a more potent lymphocyte chemoattractant than MIP-1(beta) and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1(alpha) has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1(beta) and RANTES. Recombinant human MIP-1(alpha) acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.

Catalogue number:	BS6854
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P13236
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human CCL4.
Species:	CCL4 pAb detects endogenous levels of CCL4 protein.
Molecular weight:	~ 10 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta;
Additional info:	For research use only, not for use in diagnostic procedure.

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CCL4 pAb

Cat no: BS6854

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