CCM2 (Malcavernin, Cerebral Cavernous Malformations 2 Protein, C7orf22, PP10187)

Cat no: C2105-01A

Supplier: United States Biological

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Description
Additional Information

CCM2 is a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.03-0.1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human heart lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2105-01A
Reactivities:	Human
Hosts:	Goat
Applications:	Western Blot
Size:	100ug
Form:	Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes human CCM2. Species sequence homology: canine, mouse, rat.

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CCM2 (Malcavernin, Cerebral Cavernous Malformations 2 Protein, C7orf22, PP10187)

Cat no: C2105-01A

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