CCR1 (C-C chemokine receptor type 1) is a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, expressed by a wide range of cells, which acts as a vital signal transducer for the recruitment of effector immune cells to inflammation sites, and may play a role in the regulation of Th1/Th2 cytokine responses. CCR1 binds to several immunoregulatory chemokines, including MIP-1 alpha (macrophage inflammatory protein 1 alpha), MIP-1 delta, MCP-3 (monocyte chemoattractant protein 3) and RANTES (regulated on activation normal T expressed and secreted protein). Studies have also shown that CCR1 binds with high affinity to viral MIP-2, displacing its normal ligands.
Applications:
Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistology. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 1:200; 10ul labels 10e6 cells in 100ul
ELISA: 1:50,000
Western Blot: 1:1000.
Immunohistology: 1:300
Optimal dilutions to be determined by the researcher.
Positive Control:
Tonsil or spleen
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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