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CCR2 (NT) (CD192, C-C chemokine receptor type 2, C-C CKR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, CMKBR2)

CCR2 (NT) (CD192, C-C chemokine receptor type 2, C-C CKR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, CMKBR2)

Cat no: C2099-66J

Supplier: United States Biological
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CCR2 (C-C chemokine receptor type 2 is, a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4. Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:60,000 Western Blotting: 1:1000 Immunohistochemistry (paraffin): 1:200 Optimal dilutions to be determined by the researcher. Positive Control: Spleen Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2099-66J
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 10mM KHPO4, 140mM sodium chloride, pH7.2, 0.09% sodium azide, 0.1% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes an epitope within the N-terminal region of human CCR2.

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