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CCR2, NT (Chemokine Receptor 2, CC-CCR-2, CKR2)

Cat no: C2099-91C

CCR2, NT (Chemokine Receptor 2, CC-CCR-2, CKR2)

CCR2, C-C chemokine receptor type 2, is a G protein-coupled, seven-transmembrane domain receptor protein. It has been found to be a monocyte chemoattractant protein 1(MCP-1)-specific receptor (1,2). Activation of the CCR2b isoform by MCP-1 binding has been shown to trigger intracelluluar Ca2+ flux and activation of the Jak/Stat pathway (3). A variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors (4), making elucidating their specific functions important for more fully describing the process of HIV infection.\n\nApplications: \nSuitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 1:25\nImmunohistochemistry: 1:100\nImmunocytochemistry: 1:100\nImmunoprecipitation: 1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

C2099-91C

Size

100ul

Applications

FC, ICC, IHC, IP

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1. Charo, I.F., et al. Proc Natl Acad Sci U S A. 91: 2752

Additional Info

Recognizes human Chemokine Receptor 2. Species Crossreactivity: mouse. Does not crossreact with other CKR family members.

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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