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CCR8 (Chemokine Receptor 8, CC-CCR-8)

Cat no: C2099-72

CCR8 (Chemokine Receptor 8, CC-CCR-8)

Receptors for the C-C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. The CCR8 receptor in particular mediates CC chemokine I 309 induced monocyte chemoattraction, HIV 1 envelope fusion and virus infection. \n\nApplications:\nSuitable for use in Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry and Flow Cytometry/FACS. Other applications not tested. \n\nRecommended Dilution:\nELISA: 1:100,000\nFACS: 1.3ug/10e6cells/50-100ul\nImmunocytochemistry: 1:500\nImmunohistochemistry (Paraffin): 1:400 \nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher. \n\nPositive Control:

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SPECIFICATIONS

Catalog Number

C2099-72

Size

100ug

Applications

ELISA, FC, ICC, IHC, WB

Hosts

Goat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Zingoni A et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol 161 :547-51 (1998). PubMed: 9670926.

Additional Info

Recognizes mouse CCR8 (50kD). Species sequence homology: < 50% identical to other mouse chemokine receptors in this region.

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