CD10 (CALLA, Common Acute Lymphocytic Leukemia Antigen, Neprilysin, NEP, Neutral Endopeptidase 24.11, EC3.4.24.11) (Biotin)

Human CD10 is a well known marker for common acute lymphoblastic leukemia antigen (CALLA). CD10 is expressed on normal early B cells in bone marrow and is also on fetal thymocytes. CD10 expression is lost as the T and B lineage cells mature and only appears again on activated germinal center B cells. CD10 is present on neutrophils. CD10 is a neutral endopeptidase and hydrolyzes peptide bonds on the amino side of hydrophobic amino acids.\n\nApplications:\nSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C2261-40C

Size

100ug

Applications

FC, WB

Hosts

Mouse

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride,150mM sodium chloride, 0.2% BSA, 0.04% sodium azide, 5% glycerol. Labeled with Biotin.

P Type

Mab

Purity

Purified by Protein A affinity chromatography. ~ 95% (SDS-PAGE)

Isotype

IgG1,k

References

1. H. Matsuzaki, et al, (1987) Cancer Research 47: 2160-2166. \n2. W.C. Biddle, et al, (1989) Leukemia Research 13: 699-707. \n3. H. Hara, et al, (1988) Cancer Research 48: 4673-4680. \n4. Leukocyte Typing V (S.F. Schlossman,et al, eds.) Oxford University Press, Oxford, (1995) p. 505-507.

Additional Info

Recognizes human membrane-associated peptidase CD10 at ~100kD.