Home  >  Products  >  CD10 (Neprilysin, Atriopeptidase, Common Acute Lymphocytic Leukemia Antigen, CALLA, Enkephalinase, Neutral Endopeptidase 24.11, NEP, Neutral Endopeptidase, Skin Fibroblast Elastasem, SFE, MME, EPN)
CD10 (Neprilysin, Atriopeptidase, Common Acute Lymphocytic Leukemia Antigen, CALLA, Enkephalinase, Neutral Endopeptidase 24.11, NEP, Neutral Endopeptidase, Skin Fibroblast Elastasem, SFE, MME, EPN)

CD10 (Neprilysin, Atriopeptidase, Common Acute Lymphocytic Leukemia Antigen, CALLA, Enkephalinase, Neutral Endopeptidase 24.11, NEP, Neutral Endopeptidase, Skin Fibroblast Elastasem, SFE, MME, EPN)

Cat no: C2261-50B

Supplier: United States Biological
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CD10 is a 90-110kD cell surface glycoprotein expressed on normal early lymphoid progenitor cells, immature B-cells in adult bone marrow and mature germinal center B cells in lymphoid tissue. It is also expressed in some non-lymphoid tissues such as fibroblasts, breast myoepithelium, gut epithelial cells and brush border of Kidney. CD10 is a zinc-binding enzyme with a neutral metalloendopeptidase activity which inactivates a range of biologically active peptides. It is a tumor-specific antigen expressed on cells of lymphoblastic, Burkitt's and follicular germinal center lymphoma and on cells from patients with CML. CD10 has been used as a positive immunohistochemical marker in the diagnosis of human ALL and renal cell carcinomas. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry (formalin fixed paraffin embedded): 1:20-1:30 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2261-50B
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Carrel et al. Melanoma Res 3: 319, 1993. 2. Haralambidou et al. J Clin Pathol 40: 490, 1987. 3. Kiyokawa et al. Clin Exp Immunol 79: 322, 1990. 4. Scheuermann et al. Leukemia and Lymphoma 18: 385, 1995. 5. Cutrona et.al British J Cancer 86; 1776-1785 (2002).
Additional info: Recognizes human CD10.

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