CD100, aa147-158 (Leukocyte Semaphorin)

CD100, also known as leukocyte semaphorin), is a homodimeric protein expressed on majority of hemopoietic cells ( B, T, NK and myeloid cells) and is absent from bone marrow, erythrocytes, eosinophils and endothelial cells. CD100 was shown to associate with different partner molecules in T cells such as CD45, a key molecule with protein tyrosine phosphatase activity involved in T-cell transduction, and serin kinase. It plays a role in homotypic cell adhesion and in T cell activation. It expression is increased after PHA-activation.\n\nSemaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modi?es CD40-CD40L B-cell signaling by augmenting B-cell aggregation and survival and down-regulating CD23 expression. CD72 is a lymphocyte receptor for the Class IV semaphorin CD100, which is involved in regulating B cell signaling.\n\nApplications:\nSuitable for use in Western Blot. Other applications have not been tested.\n\nRecommended Dilution: \nWestern Blot: 1:250-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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