CD105 (Endoglin, END, ENG, FLJ41744, HHT1, ORW, ORW1)

Human CD105 (endoglin) is a homodimeric membrane glycoprotein virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-1 and 3 with high affinity. \n\nApplications:\nSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2446-50E4

Size

100ug

Applications

ELISA, FC, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 50mM sodium chloride. No preservative added.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA 83: 7898-7902, 2. H. Hara, et al, (1988) Cancer Res 48: 4673-4680, 3. W.C. Biddle, et al, (1989) Leukemia Res 13: 699-707, 4. S. Cheifetz, et al, (1992) J Biol Chem 267: 19027-19030, 5. B.K. Seon, et al, (1995) Proc Am Assoc Can Res 36: 23, 6. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764, 7. B.K. Seon, et al, (1996) Tissue Antigens 48: 417.

Additional Info

Recognizes human endoglin (CD105) homodimer at ~60kD. Will augment binding of TGF-1 to CD105 expressing leukemia cells.