CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome 1)

Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-Beta receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmem-brane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic tel- \nangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6).\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C2446-50E5

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG

References

1. Bernabeu, C. et al. (2007) J Cell Biochem 102, 1375-88, 2. Zhu, Y. et al. (2003) Stroke 34, 2483-8, 3. Quintanilla, M. et al. (2003) Oncogene 22, 5976-85, 4. Dallas, N.A. et al. (2008) Clin Cancer Res 14, 1931-7, 5. ten Dijke, P. et al. (2008) Angiogenesis 11, 79-89, 6. Ferna?ndez-L, A. et al. (2006) Clin Med Res 4, 66-78

Additional Info

Recongnizes endogenous levels of human total endoglin protein.